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IQ-AI advances glioblastoma clinical trial, eyes phase two in 2025

IQ-AI Ltd

Dr Jennifer Connelly, MD, the Principal Investigator (PI) of the IQ-AI Limited sponsored phase one clinical trial that is being conducted at the Medical College of Wisconsin, joined Proactive's Stephen Gunnion with a positive update from its treatment for recurring glioblastoma patients. Connelly explained that glioblastoma, the most common malignant brain tumour, significantly impacts brain function, highlighting the importance of clinical trials to improve patient quality of life. The trial, opened nearly two years ago, investigates gallium maltolate, an oral medication showing promise in preclinical studies and animal models for efficacy against tumour cells. This phase focuses on drug tolerance, with patients reporting ease of use compared to traditional treatments and the ability to maintain normal daily activities. An expanded access programme (EAP), also known as compassionate use, has been launched by IA-AI subsidiary Imaging Biometric to allow wider access to gallium maltolate across the country, benefiting patients unable to travel to the Medical College of Wisconsin. The EAP, approved by the FDA, aims to collect additional safety and toxicity data, contributing to the trial's findings and supporting the progression towards a phase two clinical trial. The next milestone, by the end of 2024, involves concluding the phase one trial, determining the maximum tolerated dose, and preparing for the phase two trial slated for 2025, focusing on safety and beginning to evaluate efficacy. Contact Details Proactive UK Proactive UK +44 20 7989 0813 UKEditorial@proactiveinvestors.com

February 26, 2024 09:51 AM Eastern Standard Time

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Pantheon International PLC reports significant activities and optimistic outlook in interim update

Pantheon International PLC

Pantheon International PLC (PIP) has experienced a notably active six-month period, as described by Jie Gong, partner at Pantheon and co-lead manager of PIP. In an interview with Proactive's Stephen Gunnion, Gong noted that key activities included the advancement of a share buyback programme, where PIP has repurchased £157 million of its own shares out of a planned £200 million for the financial year, achieving a 3.8% net asset value (NAV) accretion. This programme aims to exploit a significant investment opportunity, demonstrate confidence in the portfolio's value, and offer shareholders a chance to sell their stakes on an equitable basis. Additionally, PIP has reworked its capital structure, notably through refinancing its credit facility last October, to diversify and secure more attractive terms. A private placement of low notes in North America was also oversubscribed, indicating strong investor confidence in PIP's portfolio. Over the six months, PIP reported a 3% increase in NAV per share amidst a quiet private equity market. Key performance indicators include an 18% growth in revenue and EBITDA across its portfolio, consistent with the five-year average. Realisation activities yielded an average money multiple of 2.5 times cost, slightly below the long-term average but still strong. The stock market performance of PIP saw an 8% increase over six months and 20% over the calendar year. Looking ahead to 2024, Gong expresses cautious optimism. Market conditions have improved, with signs of increased activity for exits and a robust valuation environment. The stabilisation of interest rates contributes to this positive outlook, though the future remains uncertain with various factors at play. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 26, 2024 09:42 AM Eastern Standard Time

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ABOUND Energy and AZUL Energy Announce Strategic and Financial Agreement to Advance Air Cathode Technologies

Abound Energy Inc.

VANCOUVER, BC – TheNewswire - February 26, 2024 / ABOUND Energy Inc. (“ ABOUND ” or the “ Company ”) (CSE:ABND) (OTC:ZAIRF) (FSE:0E9) and AZUL Energy Inc, (“ AZUL ”) are pleased to jointly announce a strategic collaboration where AZUL will engage the research capabilities and development resources of ABOUND, acting as a service provider. This collaboration will further the IP of both parties and develop additional sustainable energy solutions by combining ABOUND's air cathode technology, ZaeroTex™, with AZUL's innovative non-precious metal catalyst technology. More specifically, the objective of this collaboration agreement is to create a non-precious metal catalyst-coated electrode material, offering a feasible substitute for conventional air cathodes utilizing precious metal catalysts, which are known for their higher cost and diminished durability. Jason Birmingham, CEO of ABOUND, stated, “We are delighted to announce a significant milestone in ABOUND's strategic journey, as we secure a service contract with AZUL. This accomplishment stands as a testament to our steadfast commitment to innovation and excellence, underscoring the successful implementation of our recently announced business strategy on January 31. Resources from both parties will drive innovation, accelerate research and development, and propel the advancement of our respective technologies. This collaboration also demonstrates our dedication to leveraging ABOUND's intellectual property portfolio to support and expedite the advancement of other technologies.” ABOUND will provide its expertise regarding ZaeroTex™, an innovative flexible material designed for effectively separating gas and liquid within the fuel cell stacks of Zaeras™. This technology plays a pivotal role in optimizing cathode performance, thus contributing significantly to the evolution of the Zaeras™ Energy Storage Technology. "ABOUND looks forward to advancing our next-gen cathode technology AZUL's innovation. We're confident AZUL's non-precious metal catalyst will help further reduce material costs for our air cathode. This collaboration will contribute to lowering the $/kWh cost of Zaeras™, already positioned competitively in the energy storage market," stated Mr. Keith Morlock, COO of ABOUND. “By leveraging ABOUND’s strategic investments in our facilities, we have been able to successfully expand into Testing and Development services, capitalizing over a decade of proficiency in energy storage technology. This milestone reflects our proactive strategy, and as we propel the advancement of Zaeras™ LDES technology, it marks a pivotal moment for ABOUND.” With a commitment to maximizing the potential of the 'Air Battery' using their AZUL catalyst technology, AZUL will bring its extensive knowledge and experience to drive advancements in catalyst and cathode technologies.   Both companies share a common vision of promoting clean energies and realizing a sustainable energy economy. Koju Ito, CEO of AZUL, stated, “This partnership not only expands our market footprint in energy storage technologies and increases our visibility in international markets, particularly in North America that is the largest LDES market but also underscores our commitment to making significant strides in the clean energy marke t ” The collaboration between ABOUND Energy and AZUL Energy is effective as of April 1, 2024 for 12-month.  Both companies are excited about the possibilities that this collaboration brings and look forward to pushing the boundaries of innovation in the pursuit of sustainable and clean energy solutions.   Click Image To View Full Size   Production equipment utilized by ABOUND for ZaeroTex™ [Photo (left and right): ABOUND Energy] AZUL Energy's non-precious metal catalysts for oxygen reduction reaction [Photo (center): AZUL Energy]    About AZUL Energy Inc. Established in 2019, AZUL Energy is developing high-performance non-precious metal catalysts invented by Tohoku University for next-generation energy systems. Although precious metal catalysts such as platinum are used in hydrogen energy systems and are expected to reduce CO 2 emissions, they are costly and have significant resource constraints. AZUL Energy’s catalysts are lower cost and free of resource constraints, contributing to a more sustainable society    About ABOUND Energy Inc. ABOUND specializes in developing scalable, environmentally friendly, long-lasting energy technology. Our patented Zaeras™ long-duration energy storage technology, leveraging zinc-air chemistry, guarantees the storage and on-demand delivery of electricity without the limitations or environmental risks associated with current market leaders.   About ABOUND’s Zaeras™ Technology Zaeras™ is precision-engineered to meet future energy requirements, with a specific emphasis on simplifying long-duration energy storage. Harnessing the potential of its multi-patented Zaeras™ technology, ABOUND is poised to facilitate the seamless integration of green energy sources into the grid. This is achieved by minimizing curtailment, bridging the gap between supply and demand, and efficiently integrating green energy into the grid. ABOUND's strategic initiatives encompass opportunities for peak demand reduction, leveraging time-of-use arbitrage, participating in value stacking programs, and entering the distributed long-duration energy storage sector. These endeavors are aligned with our central objective of increasing the integration and resiliency of green energy, while stabilizing the grid. Distinguished by its inherent safety—free from fire or explosion hazards—Zaeras™ guarantees sustained capacity over an extensive lifecycle. Simultaneously, it showcases versatility by independently managing charge and discharge operations. Comparable to other Flow Battery technologies, scaling up the energy capacity of Zaeras™ is as simple as increasing the size of the fuel tank; a cost-effective solution, from kWh to MWh.  This is a welcome alternative to the fixed power-to-energy ratio constraints ingrained in traditional systems, such as Li-ion and Zinc Hybrid Batteries. To learn more about ABOUND’s technology, please visit: https://Abound.Energy    For more information please contact:   ABOUND Energy Inc. Email: Investors@Abound.Energy Ph: +1 (672) 887-9688 AZUL Energy Inc. Email: contact@azul-energy.co.jp   Notice Regarding Forward Looking Statements All statements and disclosures, other than those of historical fact, which address activities, events, outcomes, results or developments that ABOUND anticipates or expects may or will occur in the future (in whole or in part) should be considered forward-looking statements. Forward looking statements in this press release include that we may be able to continue as a going concern, that we can continue to develop a dependable low-cost zinc-air battery; that our mass storage system offers both environmental and efficiency benefits; that we can execute on our business plan as stated herein; and that we can help meet the needs for secure and reliable power. ABOUND Energy believes the material factors, expectations and assumptions reflected in the forward-looking statements are reasonable at this time, but no assurance can be given that these factors, expectations and assumptions will prove to be correct. The forward-looking statements included in this news release are not guarantees of future performance. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking statements including, without limitation: that we will not be able to secure funding in a timely manner and will not be able to continue operations; that the Company may be required to seek creditor protection, may initiate liquidation proceedings or other divestitures of its assets; the Company will not be able to pay its debts as they become due or at all; that shareholders may lose their entire investment; our Company will be able to continue as a going concern; that we will not be able to reduce operating expenditures as needed; that we may not be able to execute on our business plan as expected or at all; that ABOUND may not qualify for, or even if it does qualify, will not receive, funding from government agencies; that our technology fails to work as expected or at all; that our technology proves to be too expensive to implement broadly; that customers do not adapt our products for being too complex, costly, or not fitting with their current products or plans; our competitors may offer better or cheaper solutions for battery storage; general economic, market and business conditions; increased costs and expenses; inability to retain qualified employees; our patents may not provide protection as expected and we may infringe on the patents of others; that ABOUND may not open a manufacturing facility; and certain other risks detailed from time to time in ABOUND's public disclosure documents including the Company’s most recently filed Annual Information Form and Management Discussion and Analysis, copies of which are available on the Company's SEDAR+ profile at www.sedarplus.ca. Readers are cautioned that the foregoing list of factors is not exhaustive and are cautioned not to place undue reliance on these forward-looking statements. This news release may contain certain “forward looking statements”. Forward-looking statements involve known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Any forward-looking statement speaks only as of the date of this news release and, except as may be required by applicable securities laws, the Company disclaims any intent or obligation to update any forward-looking statement, whether as a result of new information, future events or results or otherwise.

February 26, 2024 09:01 AM Eastern Standard Time

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TRON DAO at MIT Fintech Conference and host Tron Builder Tour MIT Stop

TRON DAO

Geneva, Switzerland, February 26, 2024 – At the MIT Fintech Conference on February 23, hosted at the MIT Samberg Conference Center, the TRON DAO team made an appearance. Additionally, the TRON Builder Tour held an event at MIT venue, with over 90 attendees. David Uhryniak, Ecosystem Lead at TRON DAO, captivated attendees with his insights during the "Exploring CBDCs, Stablecoins, and Crypto Utility" panel at the MIT FinTech Conference, highlighting the crucial role of blockchain in ushering in a new technological era. This sentiment was echoed throughout the day's events, emphasizing TRON's pivotal role in the future of digital finance. Highlighting its foray into Bitcoin Layer-2 development, the TRON DAO team discussed this cutting-edge project at the TRON Builder Tour event. This initiative aims to enhance blockchain interoperability and efficiency, aligning closely with the subjects addressed during the conference and tour. The TRON Builder Tour event further spotlighted TRON's dedication to nurturing blockchain development. The event provided an ideal setting for meaningful dialogue about upcoming initiatives, such as HackaTRON Season 6, further emphasizing TRON DAO's commitment to fostering collaboration within the fintech community. There was food and drinks available to attendees and an exciting SWAG raffle occurred where lucky winners were given exclusive TRON gear and gadgets. Looking ahead, TRON DAO plans to extend the TRON Builder Tour to other universities, fostering a broader understanding and engagement with blockchain technology across academic institutions. Through its active participation in both the MIT Fintech Conference and the TRON Builder Tour, TRON DAO continues to drive forward the blockchain industry, demonstrating a steadfast commitment to innovation, education, and collaboration. About TRON DAO TRON DAO is a community-governed DAO dedicated to accelerating the decentralization of the internet via blockchain technology and dApps. Founded in September 2017 by H.E. Justin Sun, the TRON network has continued to deliver impressive achievements since MainNet launch in May 2018. July 2018 also marked the ecosystem integration of BitTorrent, a pioneer in decentralized Web3 services boasting over 100 million monthly active users. The TRON network has gained incredible traction in recent years. As of January 2023, it has over 205.11 million total user accounts on the blockchain, more than 6.96 billion total transactions, and over $20.43 billion in total value locked (TVL), as reported on TRONSCAN. In addition, TRON hosts the largest circulating supply of USD Tether (USDT) stablecoin across the globe, overtaking USDT on Ethereum since April 2021. The TRON network completed full decentralization in December 2021 and is now a community-governed DAO. Most recently in October 2022, TRON was designated as the national blockchain for the Commonwealth of Dominica, which marks the first time a major public blockchain partnered with a sovereign nation to develop its national blockchain infrastructure. On top of the government’s endorsement to issue Dominica Coin (“DMC”), a blockchain-based fan token to help promote Dominica’s global fanfare, seven existing TRON-based tokens - TRX, BTT, NFT, JST, USDD, USDT, TUSD, have been granted statutory status as authorized digital currency and medium of exchange in the country. TRONNetwork | TRONDAO | Twitter | YouTube | Telegram | Discord | Reddit | GitHub | Medium | Forum Media Contact Hayward Wong press@tron.network Contact Details Hayward Wong press@tron.network Company Website https://trondao.org/

February 26, 2024 09:00 AM Eastern Standard Time

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EtherMail Launches Email-as-a-Wallet Solution, Extending Web3 Accessibility to Billions of Users

EtherMail

Email-as-a-Wallet allows individuals to associate their Apple and Google logins with a new or existing wallet and to create Web3 email accounts, as well as buy, send and receive digital assets Users can execute ‘2 factor transactions’ (test transactions off-chain) to avoid errors, ensuring that funds will reach the intended party securely with reduced gas fees EtherMail, the platform bridging the gap between Web2 and Web3 for users and companies, has launched its Email-as-a-Wallet solution (EaaW), providing a familiar and easy entry point for individuals to explore the Web3 space. To date, the complexity of engaging with Web3 services and setting up a crypto wallet has presented significant challenges for Web2 users, who are confronted with the concept of private keys and complicated security practices, which can make the entire process overwhelming and off-putting. This steep learning curve, coupled with a lack of user-friendly tools has proven to be a major issue in terms of driving Web3 adoption. Acknowledging the chronic need for user-centric solutions to make the Web2/Web3 transition more manageable, EtherMail has launched its Email-as-a-Wallet solution. This enables users to access Web3 native protocols while staying within the familiar and comfortable parameters of email and a Gmail or Apple login, with Web3 complexity being abstracted - as illustrated in the following video demo. By allowing Web2 users to create non-custodial wallets through Gmail or Apple accounts in less than one minute, EtherMail wants to facilitate a frictionless gateway to Web3, broadening the accessibility of blockchain-based applications and services to billions of users worldwide who currently don’t have a digital wallet. Once they’ve created their Web3 email account, users can easily buy digital assets from within their inbox without having to leave the platform, greatly reducing the friction of navigating a digital assets exchange. EtherMail’s Email-as-a-Wallet solution also offers a ‘know what you sign’ feature, allowing users to easily review transaction details as an email before signing the transaction. This is particularly useful for scenarios in which users purchase an NFT on OpenSea for example, and by virtue of this feature, the email inbox serves as an aggregator of the user’s transaction history. With their Web3 email account, users can also send and receive digital assets seamlessly, mirroring the convenience of traditional payment platforms like PayPal. Users can execute ‘2 factor transactions’ – test transactions off-chain – to avoid errors, ensuring that funds will reach the intended party, with reduced gas fees. This ensures that funds will reach the intended party, while mitigating the risk of double spending when sending digital assets. The launch of Email-as-a-Wallet extends EtherMail's strong arc of growth, having long surpassed the 500,000 user milestone and secured a $4 million funding round led by Tim Draper and Draper Associates in 2023. Having previously invested in Ethereum, Tesla, Coinbase, Polygon and SpaceX, Draper has a proven track record in backing bonafide industry disruptors. Shant Kevonian, CEO and Founder of EtherMail said: “For billions of Web2 users worldwide, the prospect of creating a digital wallet and engaging with unfamiliar financial instruments has been a deterrent to exploring the Web3 space. We want to break down this adoption barrier by offering a user-friendly bridge between the Web2 and Web3 domains, extending the accessibility of Web3 to billions of users. Email isn’t going anywhere, making it the perfect mechanism to democratize access to decentralized applications and reshape how individuals interact with digital assets and blockchain technology.” Users can join the official EtherMail Telegram channel here: https://t.me/ethermail_official and follow the latest developments on Twitter: https://twitter.com/ethermail_io For more information on how EtherMail can assist projects in maintaining a direct and secure line of communication with their asset holders, users can visit https://ethermail.io/daos. Any companies interested in applying to become an applet can do so here: https://promos.ethermail.io/partnership-application About EtherMail EtherMail is the platform bridging the gap between Web2 and Web3 for users and companies, providing a familiar and easy entry point for users to explore the Web3 space. With EtherMail, companies can send rich, relevant content directly to their asset holders based on blockchain-synced real-time information. EtherMail also allows fully anonymous P2P communication and rewards its users for reading relevant content in their inbox. Contact Details ForewordVenture Lorcan Byrne lorcan@forewordventure.com

February 26, 2024 09:00 AM Eastern Standard Time

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Sui Recognized as 2024 Blockchain Solution of the Year at AIBC Eurasia Awards

Sui

The Layer-1 Received the Top Honor at the Eurasia Awards While Experiencing a Period of Unprecedented Growth and Recognition Sui, the layer 1 blockchain that has experienced explosive growth since its mainnet launch in 2023, has emerged as the winner at the Eurasia Awards held during the second edition of AIBC Eurasia in Dubai. The gala event, renowned for its world-class attendance and previous winners such as Animoca Brands and Crypto.com, witnessed the Sui Foundation being honored for the leading position the blockchain has achieved during the past months. Other nominees for the 2024 award included Near Protocol and 1inch Network. Sui’s recognition comes amidst its significant growth and influence in the blockchain space. The Sui ecosystem has gained significant traction during the past months. The layer 1 recently surpassed $600M in Total Value Locked (TVL) and secured a spot in the top 10 of DeFi ecosystems. Likewise, examination of token flows via Wormhole—a leading cross-chain protocol that supports Sui—shows that, of the almost $500M worth of funds that left Ethereum through Wormhole in the last 30 days, over 64% of it was moved to Sui. The award decision was made on February 11, while the ceremony and the announcement took place on February 25, at the Festival Arena in Dubai. Sui's dedication to pushing the boundaries of blockchain technology, as evidenced by its recent partnerships and expansions, has solidified its position as a leader in the industry. Greg Siourounis, Managing Director of the Sui Foundation, said, "It’s truly an honor for Sui to receive this important recognition from AIBC. Winning the Eurasia Award for best blockchain solution speaks to the hard work and impactful contributions of the entire Sui community including our local partners like Ghaf Labs. This award should inspire builders on Sui to continue leveraging the network’s unique advantages and also encourage new or existing projects to opt into the fast-growing Sui ecosystem." The AIBC Eurasia Awards featured a diverse array of categories, each shining a spotlight on exceptional contributions within the blockchain and gaming industry. Other notable categories included "Web3 Gaming Leader of the Year," "Crypto/Web3 Media of the Year," and "Best Metaverse Project 2024." This distinguished panel that selected Sui as the Blockchain of the Year included industry veterans and business leaders such as Olga Yaroshevsky (Ph.D. and AIBC’s Lead Producer), Pavel Matveev (CEO at Wirex), and Giacomo Arcaro (renowned seed investor and Ethereum evangelist). Contact Details Sui Team Sui Foundation media@sui.io

February 26, 2024 08:43 AM Eastern Standard Time

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U.S. Homeowners Lag Significantly Behind Their European Counterparts In Adopting Solar Power– Monalee Wants to Change That

Monalee

By Meg Flippin, Benzinga Climate tech company Monalee is looking to accelerate the adoption of solar energy for homes in the U.S. through a business model that cuts solar installation costs by half and improves convenience significantly. The company estimates that 40% of European homes have solar panels installed. In contrast, that figure for the U.S. stands at just about 3%. When it comes to residential solar adoption rates, Europe is clearly ahead of the U.S. The high cost of energy across Europe is one reason why solar is in such high demand. Pro-solar legislation and incentives are other motivators. With European energy markets expected to remain volatile, demand for solar, particularly rooftop, seems poised for more growth. In the U.S., the environment is vastly different. Only about 3% of homeowners have rooftop solar, despite it being able to save them as much as $1500 a year. Furthermore, over the last decade, solar and energy battery storage costs have fallen 85% making it more affordable than coal and other fossil fuels in many instances. Even so, widespread adoption remains elusive. The Roadblocks To Widespread Solar Adoption There are several reasons why solar adoption remains slow. America’s reliance on fossil fuels is one. As of 2022 petroleum, natural gas and coal accounted for roughly 81% of the energy production in the U.S. Fossil fuels have dominated the U.S. energy mix for over 100 years and habits are hard to break. Cost is another reason. Homeowners often cite the price of solar panels as a reason they haven’t installed them. That could change thanks to tax breaks like the Solar Investment Tax Credit, which gives homeowners a 30% tax credit for installing solar. Other state and local incentives help further defray the cost. Then there’s the solar industry’s approach to selling panels to homeowners. It’s a technology-driven field, yet the industry relies on old sales tactics and marketing messages to drum up business. Door-to-door salesmen canvass neighborhoods, often using aggressive sales tactics and promising too-good-to-be true savings. Many homeowners are kept in the dark as to the true cost and what they will save on electricity. The hard-sales approach and lack of transparency often put homeowners off. The process of getting the panels installed isn’t easy either. It takes 120 days on average from the time you sign the contract to installation. Much of that is due to the manual processes the industry uses to inspect the roof, draw up plans and get the proper permits. Every state and jurisdiction has different rules and regulations the plans need to meet. If the site inspectors, engineers and designers aren’t well-versed in residential solar, the plans may not pass, and more work has to be done. The process can seem daunting and drawn out, scaring many homeowners away. Monalee Does It Differently Monalee takes a different approach – one it’s betting will drive adoption as it eliminates all those pain points. The company relies on its patent-pending AI and advanced machine learning to make the process easier and more transparent. Their technology draws on millions of different data points to assess a customer’s roof, design a layout that maximizes sun exposure and accurately determine how many panels are needed. Then, it instantly creates an optimal solar design to match the customer’s energy needs. Something that can take days is done in minutes online. Monalee takes the middlemen – salespeople and designers – out of the equation, making the process more efficient. It can complete a site survey, design, permitting and installation within 45 days without sacrificing the quality of the materials or labor. Speed isn’t the only way Monalee is changing the industry. It's also giving customers transparent and instant pricing. Homeowners know exactly how much the system will cost and real-time pricing updates as they customize their system. All eligible federal and state incentives are factored in, and all of the fees and savings are laid out in an easy-to-read statement. There are no smoke and mirrors. To find out how much you can save with rooftop solar click here. As for the cost, Monalee is trying to shake things up in that area as well. By automating the process, it can save money, which it passes on to customers. Monalee says it can save its more than 1,300 customers in 15 states up to 50% off the total. It also backs the equipment for 25 years. The current approach to selling solar panels to homeowners doesn’t seem to be working efficiently enough, given low adoption rates. Monalee wants to change that. Leveraging technology, it is automating the process and doing it at a lower cost. It's bringing savings, transparent pricing and a speedier process to homeowners – doing its part to grow the adoption of solar energy in the U.S. To see how much you can save on a solar system click here. Featured photo by Vivint Solar on Unsplash. Monalee is a climate tech company that is accelerating the adoption of home solar, storage, and EV charging. By leveraging powerful machine learning and removing salespeople and system designers from the process, we are able to secure the same solar panel systems for homeowners at half the price compared to the top traditional solar companies in the U.S., making us the fastest, most efficient way to go solar. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice Contact Details Megan McDonough pr@monalee.co Company Website https://monalee.co/

February 26, 2024 08:15 AM Eastern Standard Time

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Better Therapeutics Follows Up Wins Including FDA Authorization For AspyreRx In 2023 With Securing FDA Breakthrough Device Designation Targeting Advanced Liver Disease

Benzinga

By Faith Ashmore, Benzinga Researchers, scientists and practitioners in the past few decades have begun to look at healthcare from a more holistic perspective, often challenging traditional medicine. The question on the minds of many is how to integrate holistic medicine into American healthcare – at scale. One company, Better Therapeutics (NASDAQ: BTTX) is doing just that and trying to revolutionize how healthcare providers treat diseases like diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Better Therapeutics is taking a comprehensive approach to address the root causes of these diseases through the development of a novel form of cognitive behavioral therapy (CBT) that it delivers digitally – enabling near-infinite scalability. Its novel form of CBT has been proven to work for the treatment of type 2 diabetes, helping patients make sustainable lifestyle changes by exploring how their thoughts and beliefs impact their actions – and ultimately their health. However, like much of holistic medicine, without proper FDA authorization and established reimbursement pathways this type of treatment is not accessible or affordable for the millions of patients who could benefit from it. Better Therapeutics has officially secured Breakthrough Device Designation for its groundbreaking CBT platform, intended to treat MASH. MASLD affects roughly 25%-30% of adults around the world, with an even higher prevalence of 75% among individuals with type 2 diabetes and up to 90% among those with advanced obesity. MASH, a more advanced form of the disease, affects approximately 20% of the 25% of American adults who have MASLD and is currently one of the leading indications for liver transplants. Despite the growing rates of MASLD and MASH, there are currently no FDA-approved drugs or devices for treatment. Milestones Hit In 2023 This news comes after Better Therapeutics’ LivVita study's results were published in the peer-reviewed journal Gastro Hep Advances, validating the CBT-based approach. The study successfully achieved its primary endpoint of reducing liver fat in just 90 days, along with significant improvements in liver health through key secondary endpoints, without any device-related adverse events. The study is the first of its kind to demonstrate improvements in various markers, such as FibroScan CAP score, MRI-PDFF, weight, ALT and FastTM score. These results suggest that the treatment has significant therapeutic potential for a larger patient population. Additionally, the study reported no device-related adverse events, even in patients with multiple comorbidities and background pharmacotherapy use. In 2023, Better Therapeutics also received FDA Authorization for its first product, AspyreRx TM, to treat adults with type 2 diabetes. AspyreRx underwent rigorous clinical testing – including a large randomized controlled trial – to demonstrate safety and efficacy. Better Therapeutics reports that the trial showed statistically significant and clinically meaningful decreases in blood sugar when compared to a control group receiving the current standard of care. Specifically, over 50% of patients achieved a clinically meaningful response, with those patients experiencing an average drop of 1.3% in blood sugar as measured by HbA1c; this is similar to what is seen in other modern drug trials. In addition, patients who used AspyreRx were also generally healthier: exploratory data revealed a range of cardiometabolic improvements, including blood pressure, body weight, quality of life, mood, safety and lower medication utilization compared to the control group. In September, the company completed enrollment in a real-world evidence program evaluating the long-term effectiveness of AspyreRx in type 2 diabetes. Given the escalating prevalence, soaring costs and growing burden of cardiometabolic diseases, there is a crucial need to revolutionize how we approach their treatment. Better Therapeutics’ revolutionary approach could open doors for physicians and patients who are looking for more effective methods of treatment. While companies like Novo Nordisk (NYSE: NVO) and Eli Lilly (NYSE: LLY) have seen success with diabetes medication, Better Therapeutics’ transformative solution may have the potential to change the trajectory of the disease. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

February 26, 2024 08:15 AM Eastern Standard Time

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Fast-Growing UK Hair Brand Glaze Set To Shake Up US Hair Category, Launching Into 354 Target Stores Nationwide and Online

Glaze, subsidiary of Waldencast UK Limited

Fast-growing UK hair brand Glaze - a subsidiary of parent company Waldencast UK Limited - expands its presence in North America with its first US physical retail partner, launching with Target starting today into 354 brick and mortar stores nationwide and on Target.com. Founded in 2021, Glaze creates accessible, easy-to-use, high-performance hair products that deliver confidence boosting, salon-worthy, glossy hair all day, every day. The brand is PETA-Certified Vegan & Cruelty-Free making it well positioned to capture the hearts of Zillennial, and the Target shopper. The brand first launched with a category game-changing semi-permanent color conditioning gloss with its distinctive, easy-to-use squeezy round bottle. They have since expanded the range into Care with GlaziPlex 4-IN-1 Super Bond Repair Treatment in September 2023 with new innovation to come being announced Spring 2024. Rolling out into Target, and supported with a nationwide US influencer campaign will be: SuperGloss Conditioning Gloss ($18.00 RRP): like a tinted moisturizer for the hair, SuperGloss is powered by KINDColor Technology to condition, care, hydrate and repair the hair as it colors for healthier, glossier, more vibrant hair in 10 minutes. In 16 shades, from a universal gloss to specific shades for highlights along with blondes, brunettes & redheads. Five of the brand’s best-selling shades will be available in-store – universal Sheer Glow, Brilliant Bronde, Glaze Cherry, Sleek Espresso and Luminous Liquorice. GlaziPlex 4-IN-1 Super Bond Repair Treatment ($22 RRP): infused with our QuadBond Technology, this conditioning treatment transforms damage to shine in just four minutes. It protects, strengthens, protects and glazes, and designed to treat all four types of damage from styling and color to chemical and heat. Waldencast Brands Chief Business Officer, Dani Viloria says, “At Glaze we are all about providing accessible, easy-to-use, high-performance products with head-turning hair results. We are so excited to be launching with Target, a retail partner who shares our vision to help US consumers nationwide achieve salon-worthy results right from their own shower.“ About Glaze: Founded in 2021, Glaze creates accessible, easy-to-use, high-performance hair products across color, care and styling that deliver confidence boosting, salon-worthy, glossy hair all day, every day. With care at their core, they are PETA-Certified Vegan & Cruelty-Free and have no parabens, no sulfates and no ammonia in any of their products. Available in the US on Amazon & Glazehair.co and in the UK on Amazon and in Superdrug. For More Information on Glaze: Website: glazehair.co Instagram: @glaze_hair TikTok: - @Glaze_Hair Facebook: @glaze_hair Pinterest: @glaze_hair Media Contacts: Amanda Smeal, amanda@amandasmeal.com Aimee Moss, aimee@aimeemoss.net Contact Details Amanda Smeal amanda@amandasmeal.com

February 26, 2024 08:08 AM Eastern Standard Time

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