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Variational AI Files Two US Provisional Patents for Potential COVID-19 Drug Created by Generative AI

Variational AI

Variational AI, developer of the Enki™ generative artificial intelligence (AI) drug discovery platform to redefine the economics of drug development, today announced that the company has filed two provisional patents with the United States Patent and Trademark Office (USPTO) related to new chemical entities (NCE) successfully created using generative AI. Variational AI’s protease inhibitors are among the first NCEs created via a purely generative model and will be useful in the development of COVID-19 drugs as part of the company’s coronavirus antiviral program. Of even greater significance, this method underscores the potential of generative AI to create novel, efficacious, safe, and synthesizable molecules. “The filing of these patents is a concrete milestone not just for Variational AI, but for the applicability of generative AI to the domain of drug discovery,” said Handol Kim, co-founder and CEO, Variational AI. “Whereas adoption of AI for drug discovery is accelerating, until now it has been based on older discriminative models. Though powerful, these models are essentially just performing faster and better virtual screening of known or existing molecules. Enki™ does not screen, but rather truly creates new molecules, similar to how other generative AI models like DALL-E and ChatGPT create novel images and text based on prompts. In our case, we use the language of chemistry as prompts to describe the molecules we want.” While generative AI has recently been applied at scale to the creation of novel images, text, music, video, and software code, the successful application of generative AI to drug discovery is still nascent but potentially transformative. Variational AI’s platform created two novel lead candidates that each bind differently and distinctly to the SARS-CoV-2 main protease, the most promising therapeutic target implicated with COVID-19 across variants and potentially other coronaviruses. The platform is based on a generative model framework known as a variational autoencoder (VAE) and created these lead candidates after being trained on large sets of public and proprietary data including older SARS-CoV (SARS) main protease data. The candidates demonstrated potency, selectivity, and novel binding modes on the SARS-CoV-2 main protease that show potentially better safety profiles compared to the existing standard of care. Variational AI is now focused on training Enki™ for multiple drug targets in oncology and making rapid progress in this disease area, leveraging learnings from its success in antivirals, as well as other disease areas. “Our team of machine learning researchers has been developing and applying generative models for years, long before the recent interest,” said Jason Rolfe, co-founder and CTO, Variational AI. “Drug discovery is a massively difficult undertaking, yet we continue to make rapid progress working hand-in-hand with our drug discovery team as we move to addressing unmet medical needs in oncology and beyond.” Funding for this work was supported in part by Canada’s Digital Technology Supercluster in collaboration with adMare BioInnovations and the University of British Columbia. About Variational AI Variational AI uses generative AI to create novel and diverse compounds that are optimized for multiple properties to avoid the most common causes of drug attrition and increase clinical probability of success. Variational AI works with leading biopharmaceutical partners and is developing its own internal pipeline. To learn more, visit https://variational.ai. Contact Details SVM Public Relations Jordan Bouclin +1 401-490-9700 variationalai@svmpr.com Company Website https://variational.ai/

January 05, 2023 10:00 AM Eastern Standard Time

News Release

10 Best Essay Writing Services in the USA: TOP College Paper Writing Websites

Genuine Papers

A stitch in time saves nine. So, as a student, you may want to ask, “Can I prevent low grades in my academic essays?” The answer is yes, especially with the assistance of paper writing services waiting for you to take advantage of their experienced writers. But are you ready to meet them? Before sharing this list of the TOP rated essay writing companies in the United States, you should know the criteria for choosing these websites. To start with, they have excellent writing consistency with many repeat customers. Furthermore, first-time buyers often commend them for quality and prompt delivery. These services have respect for deadlines and submission dates, making them the joy of many students worldwide. Again, these are the best American essay writing services available online today, because of their excellent customer support. Their customer care team is fully armed with all it takes to answer all your inquiries and tend to questions posed to them when you reach out. Also, they keep tabs on your order on their platform. If you are looking for more reasons to check them out, know that when you hire them, you will receive plagiarism-free content. That is, your essay is original. Thus, you would not have to worry about it being flagged by your professor or any plagiarism checker software. All you have to do is check the internet for more proof of excellence. The digital world is littered with many positive reviews. So, do you want to be one of their lucky customers? To make things much easier for you, we have provided a well-curated list of the best essay writing services in the next college season in the United States. These companies were well researched and added to this updated in January, 2023 rating based on excellent turn-ins over the years from their clients and prompt delivery. The List of the 10 Best Essay Writing Services in USA PaperHelp - the best college essay writing service today in the United States. 99Papers - recommended for New York students. SpeedyPaper - same-day writing company. EssayPro - the cheapest U.S. paper writing provider in 2023. MyAdmissionEssay - the best essay service in Florida. EssayBox - a professional American website to hire writers online. IQEssay - "do my essay" qualified writers from Ohio. Studdit - newest company to buy an essay from Texas. SuperbPaper - company from Arizona that can write your essay. PaperCoach - trusted MBA essay writing service est. 2012. Now, we can see what advantages they have and what features they may cover for students looking to get the best service for their grade. Let's check full trusted reviews from experts for each website. 1. PaperHelp PaperHelp is one of the most popular essay writing services in the United States today. And their place in the market is that of the top seat in 2023. Well, they go to that level from sheer grit in their excellence creed since their inception in 2008. And that is reflected in the quality of their deliveries to their customers. When you order from them, they strive to give an experience commensurate with their creed of being the best essay writing service. The reason for that is not far-fetched. They simply realize that human referrals are the best way to keep their business booming. So, if they make you feel good, they have invested in their publicity among your friends and colleagues in school. Ordinarily, you are bound to get hooked on their website. Most customers buy from them because of how super intuitive their interface is. It is both easy to understand and navigate. The website layout, design, graphics, and interactions are cool, making you stay on the website long enough to order from them. All these contribute to their efforts to give you the best experience possible as you order. Thus, they do not only deliver excellent written-from-the-scratch content for you, but they also make sure that your process of ordering and getting the content delivered to you is as seamless as possible. Their customer journey reflects how much they put into your work to make t come out beautifully. Now, nice graphics aside, can they write your essays well? With tons of feedback, reviews, and comments from many reliable sources, PaperHelp does not only have first-time buyers. They have a ton of repeat buyers who are always on edge to order from them. Why? Because the platform delivers excellent delivery to them all the time. So, why go elsewhere when I am being served excellently here? Right? Thus, you should know that PaperHelp creates fresh content for your essays and promptly delivers with 0% plagiarism. And they can also tend to all forms of essay writing services you might require. That is, from a highschooler essay to the most academically complex ones such as Ph.D. dissertations. All are welcome and can be excellently written by their professional writers. Speaking of professional writers, they have an army of seasoned writing specialists with rich academic writing experience. Most of these writers are academics themselves. So, they are familiar with the in and out of the most complex essays, theses, and dissertations. On the PaperHelp platform, these writers can turn in essays with an urgent deadline as fast as 3 hours. And with just $10.00, you can have a good paper written for you. Also, you can monitor the progress of your work on the control panel with options for other means of communication, such as toll-free numbers, Skype, Facebook Messenger, and the PaperHelp app. 2. 99Papers Are you a New York student? Then get in here. 99Papers is perhaps the best writing service you will encounter as a student. As one of the oldest platforms, they have rich experience in how to write essays for varying academic difficulties. All you have to do is order from them and see the magic. You may be wondering what is unique about them. Of course, their existence is a distinctive factor. However, it is not the major propelling reason many people buy from them. They simply deliver quality. This feature stands out to most of their customers. They create original essays, not plagiarized ones. They offer plagiarism reports on request. Further, they have a considerably low-price range for an essay per page. By the way, they are one of the essay writing services with a wide range of essays they can write. Whether you are a high schooler looking to work on a mini-essay or a full-blown academic looking to get an A in your dissertation as a Master's student, all of your writing needs can be well met at 99Papers. And with just $9,95 per page, you get access to a well-written essay. This is coupled with several discounts on their website that you can benefit from when ordering, especially if it is your first order. You also enjoy some premium features with this piece, such as proofreading or plagiarism check. Unlimited revisions, bibliography, and title pages are also free of charge on their platform. Little wonder many students looking for where to save some buck and still get stellar work opt for this writing service. Also, 99Papers places a premium on their writers. They are quite strict on the admission of people into their writing intelligentsia. They verify their writers' academic backgrounds and only hire those with rich writing and knowledge experience. Interestingly, some writing experts work in reputable universities such as Yale, Cambridge, Oxford, Berkeley, etc. All these extra efforts in recruitment are so that they can always serve the customers with only quality orders. Similarly, their customer support is also made of quick-response and prompt personnel. Do you know that their average response time is 10 seconds? Yes, that is quite remarkable for a company as big as that. 3. SpeedyPaper This essay writing service is called SpeedyPaper for a reason! Their response rate to essay delivery is one of the fastest in the entire American market. And it is one of their major selling points. Most of their buyers, mostly from California, reach out to them when they need an essay written within hours. And when you make this kind of quick order, their prices do not unnecessarily shoot off the roof to scare you away. No. Another thing that stands out for most people is the level of quality retention. That is, their essays are both quickly done and excellently written. With them, you can expect your essay to be well-researched and grammatically compliant without plagiarizing or stealing from another source. If you need an essay in 6 hours, they can take on the order and deliver it efficiently. Further, if you are looking for a synonym for SpeedyPaper's support team, the phrase you are looking for might be "as fast as lightning". They respond swiftly to all new buyers' inquiries, complaints, and comments from their current customers. Little wonder they have an outstanding reputation in public for their beautiful work culture and customer relations. They also have a high rating with many review sites that have taken a recount of how good their service is. The customer support swiftness is part of the SpeedyPaper attempt to make your order from them and enjoy one of the best customer services out there in the essay writing services space. In addition, their pricing is quite affordable for most people. Their rates start at $9 per page for high-school-level writing on a 14-day deadline. However, several things may affect the price by lowering or increasing it. And one of these is the use of coupons on their websites. That might lower how much you have to pay cumulatively for your order. If you request a plagiarism report or the deadline for your turn-in is shorter than usual, you might have to pay more than what you would ordinarily have to pay. 4. EssayPro If you mention the names of the best cheap essay writing services from U.S., EssayPro will make its way to that updated list. The reason for this high ranking is not far-fetched; they have etched a distinct experience in the minds of all their customers. And that is the fact that they offer a wide range of services on their platform. With all the different forms of essays you can get with them, you can also rest assured that your orders are safe and will be done to your taste. They do essay writing, editing, rewriting, as well as proofreading. Many buyers have found themselves iterating between EssayPro and other writing services, yet choosing the former every time they are left to pick where to get their essays done. This shows that this writing service is trusted by many in the market. Checking out their website gives you a lot of straightforward ease with ordering. For example, the first thing you see on their website is a price calculator. It asks for your preferences, such as the paper's type, length, and deadline. This is to determine a minimum price per page. You can get a well-written essay for just $10.8 per page. And that is especially if the deadline is around 5 days. However, depending on the academic difficulty and the short deadline involved in the order, the price might go up to around $14.36 per page. And the price is quite reasonable compared to many other services in the market. Further, EssayPro also runs discounts that many of its buyers look forward to. Usually, the discounts depend on the number of pages you are ordering and the times you have ordered from them. The discounts range between 10% to 33%. Also, their FAQ section reveals that there is a referral program. And you get a $10 PayPal transfer when you bring a new customer, and they order from their platform. 5. MyAdmissionEssay Are you in Florida and looking for the “write my essay service” you should patronize? Then your search has ended. EssayFactory has proven itself as a strong name for delivering excellent content for its customers. They are known for creating from-the-scratch content with no plagiarism. They are so confident in their essays that they are willing to provide plagiarism checks for all that request them. As a result, many students have made them solace when it comes to writing excellent essays to achieve better academic results. Be it a high school grade essay or more academically difficult ones such as theses or dissertations; they are ready to woe your teachers and supervisors with their excellent writing skills. Furthermore, they have such a good reputation for their writing in the USA because of their team of expert writers. These folks strive to achieve top-grade writing every time they touch the keyboard. Every time they write, their works go through a thorough and immersive plagiarism check and review before such a paper is delivered. As a result, they ensure minimal to zero grammar or spelling mistakes. Not only that, but they also ensure that you receive prompt delivery of your order. Interestingly, they have one of the best support teams in the industry. Their customer support teams are available 24/7, and they are ready to attend to all your inquiries and complaints if you ever have any. They are also known for fast response and finding the best solutions that suit you as an individual and not generic responses that would put you off balance. They are available to speak to you via chat or phone. You can also access them via the email indicated on the website. 6. EssayBox EssayBox is another notable name in the U.S. essay writing service market. From ordering on their website to receiving your order, this writing service strives to give you a seamless experience with getting your essay written on their platform. Whether it is a basic high school essay or a full-blown dissertation or thesis, you can rest assured that you will be getting good and original content at the end of the delivery. Ordering on their website is quite easy. And this is because their website is suited to give you a great welcoming experience. And it is designed so that all the necessary infographics, promos, discount codes, reviews, and price calculators are available at first contact. Also, the color scheme is carefully chosen. It does not disturb or distract the eyes from the most important details needed. You can put your heart at rest when it comes to the quality of writers on their platform. This is because they hire native speakers who can write effectively in UK English and the US. Their writing specialists undergo some language tests before allowing them to take orders on the platform. Thus, as a customer, you can choose the writer you would like to attend to your order based on their qualifications, field of expertise, and experience. In case you are wondering, EssayBox charges $12 per page. However, depending on the specifications of your order, there might be a few tweaks to the eventual price. These specific adds could be the academic difficulty of the paper, deadlines, the number of pages, topics, etc. In addition, they offer services like revisions, inquiry, titles, outlines, and bibliography for free. 7. IQEssay IQEssay is that one-stop shop for all of your essay writing needs. You need not stress too much about most of their papers. Their customers trust them to deliver quality all the time. This is attested to by innumerable comments, reviews, and positive feedback they have garnered over the years of working as a top-notch essay writing company based in Ohio, USA. They are another writing service that most USA students rush to when they need their assignments done. This is because they not only have a sterling reputation for excellent papers written for you, but also deliver your papers promptly. Thus, if you are looking for expert writers from the U.S. who can give you a great paper within a short time frame of delivery, you can check out IQEssay. Since 2005, they have specialized in making geniuses of many students by assisting with papers ranging from short essays to exam notes, proofreading, and editing, or a full dissertation. They also offer some services not common to most essay writings service. And one of them is a CV writing service. They also write personal statements, assignments, etc. In short, they are available to help you to achieve your academic, business, or even personal goals. And with all these, you can be at rest of a high standard work to be done on your work. Not only that, but they also respond promptly to all of your orders regarding delivery. The pricing of IQEssay, like every other platform in the market, can be influenced by the order's specifications. You can get an excellent article within a 30-hour delivery for $30 per page. And this price is influenced by the caliber of writers that work on your order. Also, they give their customers discounts that aid their pay on the platform. A good example is the 20% slash on orders if you are buying paper from them for the first time. 8. Studdit With hundreds of positive reviews about them from Texas college students, Studdit has a strong root in the industry as one of the strongest names. This reputation is one of reliability and trust. They will write your essay and other related writing services like a CV from you from scratch. Not only that, but you would also be able to present a plagiarism-free essay to your supervisor for your dissertation and theses. Little wonder many students keep going back to them to write their academic essays, difficulty level notwithstanding. Thus, whether you are a high schooler needing an assignment written or a postgraduate student looking to wow your supervisor, all writing needs are ably met on the Studdit platform. Further, Studdit can brag of sterling, original, and quick content because of their team of writing specialists. This platform particularly has a great knack for treating its writers well. This unique in-house culture culminates in palpable enthusiasm with their writers to deliver promptly on the tasks assigned to them. As a writer with them, you will not be given a new task unless you have completed the one on your hands. Also, writers are rewarded for bringing clients to Studdit. So, there is enough motivation to round. Thus, you can be assured that, as a client, your essay is being handled by someone happy to do their job. Also, note that Studdit is one of the cheap essay writing services in the market. With just $10, you can get a great paper delivered to you. Also, you could experience the prices jerking up or remaining normal depending on your academic level. However, this does not in any way tamper with the quality of your paper. 9. SuperbPaper SuperbPaper is an Arizona essay writing company that priorities excellence in writing, delivery and discounts. They are also known as the first-class, affordable essay writing service. And this is because they deliver premium quality papers from professional writers and editors. These expert writers that work on their platform create stellar and original content for each student who orders essays on their platform. Also, they deliver their essays speedily. Thus, they respect deadlines and communicate effectively with you. Further, irrespective of your academic level as a student, SuperbPaper is that one-stop shop writing service ready to take on any form of paper. That is, term papers, dissertations, theses, research papers, high school essays, etc., are all what they excellently write on a day-to-day basis. And you can enjoy their services on these essays from $9 per page, depending on their difficulty level. Many customers go back to SuperbPaper because of the laudable work that their customer support team does. They respond to inquiries and complaints quickly. Also, they are available for you throughout the day. 10. PaperCoach PaperCoach is a U.S. writing service that attends to your writing needs. Once you have supplied your order specifications on their website, you are good to go on your order. The writer begins to work on it immediately. Little wonder any student entrusts their MBA essays in the hands of this company. PaperCoach will write you original content from scratch. Also, their content is entirely plagiarism free. Thus, you do not have to be afraid of plagiarism checkers flagging your MBA essays or your supervisor thinking you are fraudulent in any way. PaperCoach has enjoyed a lot of great reviews in the market over the years. And rightly so! The reason for this positive feedback is not far-fetched. The most notable point in most comments is how they quickly turn in client orders. Thus, if you are a student pressed for time, make sure you reach out to PaperCoach, as they are one of the best MBA essay writing services in the industry that prioritize prompt delivery of essays. The writers who work on these original and prompt contents are in categories. You have an opportunity to pick the ones you prefer to work on your order, only that it might increase your price a little. This service also has a strong support team always available to you. They are ready to answer all your questions, including pricing. So you can rest assured that you will get a special delivery at $8 per page. FAQ How an essay writing services work? American essay writing services are one of the easy-to-navigate services in the world presently. And you do not need to search all over the internet to find them. We have carefully curated them for you above. So, as highlighted above, you can choose any of the best essay writing services in 2023. But note that ordering most of these writing services is quick to understand. You do not have to struggle much with them. Most of what you need to make a successful order is on their website. Most of these writing services have great website interfaces. And on these sites, you would be met with a price calculator. This is where you customize your order by adding the essay specifications. That is, you would input the deadline, number of pages, topic of the essay, etc., in the form that doubles as a price calculator. Thus, your essays would be automatically calculated, and you make payments via any channels shown on the site. Then you are good to do! Also, if you have any questions, you can contact customer support on any of these platforms. They are available 24/7 and ready to resolve all your complaints. How much does it cost to order a college paper? The price for ordering a college paper varies. The essay writing service that you choose determines what fee you have to pay. For 99Papers, you enjoy their services and excellent essay delivery for just $9,95 per page. And for PaperHelp, you can buy an essay for $10 per page. These are the base process for these essay writing services. Thus, depending on a couple of factors, your eventual price to be paid might increase cumulatively than what could pass for the normal gross price fee. Some of these additions that jerk up the essay price include the date or time of the deadline. You might have to pay more for the different deadlines if it is much shorter than the stipulated time. The academic level also determines the price. Most of the base prices on the websites are for high school and college undergraduates. For dissertation students, the price might increase. Other factors include special services such as plagiarism reports, the type of writer working on your order, etc. Some platforms also offer discount coupons, so you can leverage that for your fee. Are using an essay writing services in the USA ethical? Yes, there is nothing wrong with using essay writing services. It is legal and ethical to use the help of expert writers to assist in your essays when you cannot work on them yourself. This eases the burden on you and allows you to focus on most things you need. Most of the essays are written from your order specifications. Thus, you are guiding the mind of the writer to help you write based on the resources you have made available. Students who are the breadwinners of their families or those who work two jobs to support themselves through school are incapable of writing essays. There are even students without a proper grasp of the English language. How can they write essays and score high grades in their academic pursuit? Asking for help is not a bad thing and would not be one. Using the services of an essay writing service is simply asking for help from an expert writer. And that's okay and cool. Legitimacy of buying an essays in the United States Buying essays in USA online is 100% legit. However, it depends on where you decide to buy your essays. If you decide to buy them from unverified sites or platforms, you are left alone to face the brunt of whatever comes your way. But to avoid this, we have listed and carefully explored each service we consider the best in the market. And they are all completely legitimate. No need to fear using them. Just get your purse ready and order away! Most of them have a lot of online reviews, so you can check them out before putting your money on any of them to make an essay purchase from any of their writers. Further, you would get fully original content from these websites. Not plagiarized ones that unverified sites bring your way. So, you do not need to be afraid that plagiarism checker software will flag your content or that your supervisor will think you stole the research from somewhere. You would enjoy complete transparency with excellent content delivery. That sound like a legit platform to us. Don't you think? In the same vein, all the credentials that you submit on the website are treated as anonymous and confidential. So they cannot be shared anywhere online. What is the best essay writing service in the USA? PaperHelp is a top-rated American essay writing provider in 2023. They are rated this high because, with them, you enjoy a maximum pricing advantage compared to most platforms in the market. For only $10, all your writing needs can be met per page. And you would be taken aback at the level of excellence that has gone into the production of each original content of your essay. At the same time, the work would be delivered swiftly without tampering with the quality of the content. You can enjoy all these freebies and more with revisions on the PaperHelp platform. And in case you have any inquiries, you can easily contact their customer support team, who are always hands-ready to pick up your call or chat with you via any of their social media handles, especially Facebook Messenger. You can also choose to speak with them via phone if you so choose. How to hire somebody, who can write a professional essay for me? There are tons of ways to hire somebody to write essays for you. However, many of these paths lead to meeting the wrong folks on the internet. Fraudsters posing as good essay writing services are very rampant these days. And the only way to interact with trusted and reliable professional services online is via the lists of services we have made available above. These have a simple approach to ordering from them. And they are always ready to be hired to work on any of your writing needs that might surface at any time. Hire somebody to write your essays for you is easy today in USA. Since you have the internet and can scroll through, you can access the above-mentioned platforms. So, if you are a student on the lookout for platforms that can help you best craft a great paper that would make your supervisors smile at you, then consider using any of the services listed above. They have been carefully curated just for you for this purpose. A few words in conclusion Your future is in your hands. Likewise, a sage affirms that a man is the architect of his destiny. This means that, as humans, we can pick from available options and carefully plan for the life we want to see. The same goes for you as a student today seeking to be one of the best in his class or level. The truth is, it is your choice to either ask for help or not. If you cannot write your essay, contacting professional essay writing services in the USA would be a great choice. Seeing that the essay writing services highlighted above are available to tend to all the writing needs of students, it becomes easier to pass courses. Most courses and subjects have a larger chunk of their marks allocated to assignments and papers/essays, which expert writers are ready to take; perhaps you cannot do it. Even if you can but still require an expert's perspective, you should buy your essay from these platforms. Take a step in the right direction toward your stellar academic future today! Contact Details Martina Brenwood usa_writers@best-essay-services.com

January 04, 2023 11:15 PM Eastern Standard Time

UNOS Leadership Requests USDS Engagement Concerning Leaked Report and Impact on Patients

United Network for Organ Sharing

Senior leadership at United Network for Organ Sharing (UNOS), the federally contracted non-profit that unites the organ donation and transplantation community and serves as the Organ Procurement and Transplantation Network (OPTN), have raised concerns with a draft report by the United States Digital Service (USDS). In a letter sent today to USDS Administrator and Deputy Chief Federal Information Officer Mina K. Hsiang, UNOS leadership shared that in 2022 its organization received a supposed draft report by the USDS concerning its information technology (IT) systems. The letter was authored by UNOS Board President Dr. Jerry McCauley, Vice President/President-Elect Dr. Dianne LaPointe Rudow, Past President Dr. Matt Cooper, Vice President of Patient and Donor Affairs Valinda L. Jones and Interim CEO Dr. Maureen McBride. “As noted in an August 2, 2022, letter to the HRSA Administrator, we would have welcomed a USDS review of our system, but did not receive notice of this review before, during or after its development, nor are we aware of a final version of the document,” wrote McCauley, Rudow, Cooper, Jones and McBride. “A safe, reliable, and secure technology infrastructure for the national donation and transplantation network is of critical importance to the public and the patients we all serve, and UNOS would be pleased to support the USDS’ work in updating and finalizing the report.” The leaders went on to request a meeting with the USDS to mutually review and discuss the draft report and invited the USDS to conduct an in-person review of its IT systems. The report, which was leaked to members of the press last summer, served as the basis for public discussions surrounding the IT infrastructure for the national donation and transplantation system. Routine audits of UNOS technologies are performed by the Health Resources and Services Administration (HRSA) and have not identified the findings outlined by the USDS report. “We believe both UNOS and the USDS want the same thing: to get as many donor organs as possible to the patients who need them, both equitably and efficiently,” wrote McCauley, Rudow, Cooper, Jones and McBride. “We both want to improve organ donation and transplantation in a way that’s based on facts, and without service interruptions in a system upon which so many patients, professionals and clinicians depend.” A safe, reliable and secure IT infrastructure is instrumental to the continued success of the U.S. organ donation and transplantation network. The IT system that powers the OPTN is highly effective and secure, helping make over 41,000 transplants possible per year nationwide and fending off over 3,000,000 hacking attempts per day. Also copied on the letter were HRSA Administrator Carole Johnson, HRSA Acting Associate Administrator Suma Nair, HRSA Chief Information Officer Adriane Burton, U.S. Chief Information Officer Clare Martorana and U.S. Office of Management and Budget Director Shalanda D. Young. A copy of the full letter can be found here. About UNOS United Network for Organ Sharing (UNOS) is a non-profit, charitable organization that serves as the Organ Procurement and Transplantation Network (OPTN) under contract with the federal government. The OPTN helps create and define organ allocation and distribution policies that make the best use of donated organs. This process involves continuously evaluating new advances and discoveries so policies can be adapted to best serve patients waiting for transplants. All transplant programs and organ procurement organizations throughout the country are OPTN members and are obligated to follow the policies the OPTN creates for allocating organs. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

January 04, 2023 02:36 PM Eastern Standard Time

Programming, Writing and Research skills dominate the freelance job market

FREELANCER.COM

Freelancer.com (ASX: FLN) (OTCQX: FLNCF), the world’s largest freelancing and crowdsourcing marketplace by number of users and jobs posted, today released its quarterly Fast 50 Index for Q4 2022. The index, which is based on data from 372,000 jobs posted on Freelancer.com between October 1 to December 31st 2022, ranks programming, report writing, and research related jobs among the fastest growing skills on the platform. At the end of the year, many businesses and companies often rely on freelancers to assist with high volume tasks. According to the Q4 data, the leading tasks for the end of 2022 were Report Writing, Research and Technical Writing. These job types were trending as employers were hiring freelancers to support them with compiling 2022 retrospective reports, creating strategic plans for 2023, and writing business reports. Research jobs also spiked as many entrepreneurs aim to start businesses in the new year, increasing the number of market research and business plan projects posted to the platform. Report Writing (up 59.5%, from 3,374 to 5,384) takes the number one spot in the index when ranking the percentage growth of more than 2,000 skills available on Freelancer.com. Coming in a close second is the skill Matlab and Mathematica (up 56.4%, from 1,250 to 1,955), which are separate programming languages used by engineers and scientists to analyze data. Research jobs and Research Writing rank as the third and fifth fastest growing skills, up by 36.3% (from 3,905 to 5,325) and 32.1% (from 7,527 to 9,944), respectively. Top 5 Fast Growing Skills for Q4 2022: Report Writing - up 59.5% Matlab and Mathematica - up 56.4% Research - up 36.3% Web Scraping - up 32.6% Research Writing - up 32.1% A sudden increase in projects for tech and IT related skills on Freelancer is a continuation of the trends observed in Freelancer’s Fast 50 for Q2 2022 and Fast 50 for Q3 2022 - where freelance jobs for software, app and website developers surged as a result of global tech layoffs. In Q4 2022, the data reveals the new trend is employers hiring for programming jobs, as skills specific to programming dominated the rankings. Web Scraping, often used for lead generation and price monitoring, came in as the fourth fastest growing skill, increasing by 32.6% (from 3,891 to 5,162). C Programming and C++ Programming, general-purpose programming and coding languages used to develop systems and applications, increased by 28.9% (from 4,974 to 6,415) and 23.7% (from 4,775 to 5,907), respectively. Jobs requiring skills in Python, a high-level, general-purpose programming language, also grew by 20.7% (from 10,712 to 12,931). Adding to the growth of engineering-related programming Matlab and Mathematica, projects seeking skills in Engineering also increased in Q4 2022 with Electrical Engineering jobs growing by 25.6% (from 2,305 to 2,897) and Mechanical Engineering jobs increasing by 17.3% (from 1,544 to 1,812). “The latest index truly demonstrates the breadth of skills and jobs available on our platform. We have employers turning to freelancers for content jobs, such as writing and research projects, all the way to highly complex jobs like mathematics, programming and engineering. The trend that we continue to see is the surge in tech-related projects as a result of global tech layoffs,” said Matt Barrie, Chief Executive at Freelancer.com. While programming specific skills grew in Q4, other tech-related skills ranked as some of the fastest falling jobs of the quarter. CSS3, an advanced language used to style web pages, ranked as the fastest falling skill and was down by 67.8% (from 1,227 to 395) in Q4 2022. A similar skill for web page development called AJAX also decreased by 51.8% this quarter (from 1,763 to 849) after ranking as the second fastest growing skill in Q3 2022. As both of these website development skills decreased, jobs relating to WordPress and general-purpose scripting language used in web development called PHP increased significantly. Projects for WordPress increased by 12.8% (from 17,275 to 19,499), while projects for PHP increased by 8.1% (from 44,333 to 47,937). PHP also ranks as the second most in-demand skill on Freelancer.com in Q4 2022. Top 5 Fast Falling Skills for Q4 2022: CSS3 - down 67.8% Angular - down 58.3% API Integration - down 55.3% Data Extraction - down 53.2% Blog Writing - down 53% Fast 50 Q4 2022 Trends & Analysis Demand shifts from niche IT skills in Q3 to Programming in Q4 While technical skills have always been sought out on the Freelancer platform, global layoffs are causing increases in niche tech skills and unprecedented fluctuations in demand. In the previous quarter, Freelancer uncovered the trend of employers turning to the platform to hire highly skilled IT and tech specialists to support following mass tech layoffs. Tech-related skills made up 40% of the in Q3 2022, with Android App Development, AJAX and API ranking as the three fastest growing skills. A similar trend was also observed in Freelancer’s Fast 50 for Q2 2022 as Software Development ranked as the quarter’s fastest growing skill, up 47% compared to the previous quarter. This quarter, the demand for tech skills continues with employers hiring Programming related skills. Matlab and Mathematica, Web Scraping, C Programming and Python experienced the highest percentage growth for programming skills in this quarter’s index. Other increases include C# Programming up by 11.2% (from 5,986 to 6,657), JavaScript up by 9% (from 17,439 to 19,010) and PHP up by 8.1% (from 44,333 to 47,937). On the other hand, application development saw a decrease in demand in Q4 2022. Jobs requiring skills in Angular, a platform for building mobile and web applications, decreased by 58.3% (from 1,459 to 608). Projects seeking App Developers dropped by 52.2% (from 1,196 to 571), while projects for Android App Development fell by 49.4% (from 1,948 to 984). “Mass layoffs in tech are causing ripple effects as companies scramble to plug skills gaps within their organisations. We’re observing this in waves. As the tech giants lay off staff, we’re seeing employers lean on freelancers for support with tech-related skills. Last quarter, web and app development was in-demand, but this demand has now shifted to programming with increases across the board for many programming language jobs. In 2023, we can expect to see more demand for tech related skills on Freelancer as layoffs continue and employers look to hire on-demand freelancers,” said Barrie. Generative AI leads to spike in Machine Learning Jobs The second half of 2022 saw significant leaps in Artificial Intelligence and Machine Learning. Public access to powerful generative AI tools - such as Stable Diffusion, Dall-E, OpenAI’s GPT-3 and ChatGPT - which are now changing the way designers design and writers write. This is now bleeding into other business areas. Since the release of Chat GPT on November 30th 2022, there have been 26 jobs posted on Freelancer in December that aim to harness the power of generative AI. Many of these projects are seeking AI and Machine Learning experts to help create chatbots, assemble GPT-3 and Stable Diffusion workflows when transcribing video, and integrating Chat GPT-3 to websites. As a reaction to these new technologies, there has been an increase in Machine Learning jobs in Q4 - up by 26.6% (from 2,215 to 2,809). Projects for Machine Learning, AI and Deep Learning are only expected to increase as more businesses become aware of these tools and their potential to integrate them across their business. “There has been an absolutely transformational step that has happened in the last few months with Artificial Intelligence, Machine Learning and Deep Learning. Any creative task man can do, AI can or will be able to do better. Leaps in AI will affect every facet of business. Not just in years, but potentially within months. Companies, businesses and startups are taking notice and exploring ways of harnessing these new tools,” said Barrie. Search Engine Optimisation (SEO) jobs continue surge, Search Engine Marketing (SEM) bounce back from Q3 slump The first expense most companies cut in a downturn is paid advertising. In Q3, Freelancer observed a shift in advertising behavior as employers turned away from paid advertising or SEM projects and began hiring freelancers for more traditional marketing or SEO projects. In this quarter, we’re seeing these companies turn back to SEM and Google Adwords, as well as continue their efforts to improve their SEO. Jobs for Google Adwords increased by 21.4% (from 2,221 to 2,697), while Web Search jobs grew by 15.8% (from 4,111 to 4,763) and SEM-related projects increased by 12.9% (from 1,597 to 1,804). For freelancers, projects relating to SEM are some of the highest paying job types on the platform. On average, Search Engine Marketing jobs pay US$2,231 per project. SEO jobs also pay relatively high on the platform with an average of US$1,704 per project. The areas that did see a noticeable decrease in jobs posted in Q4 2022 compared to Q3 were Creative Design (down by 48.2%, from 1,309 to 677), Content Creation (down by 41.9%, from 1,181 to 686) and Advertisement Design (down by 38.6%, from 1,754 to 1,077). 2022 Fast 50 Reports track major crash in Bitcoin, NFT and Ethereum Each quarterly edition of the Fast 50 Index for 2022 has tracked the rapid rise and fall of freelance crypto and NFT related jobs. At the beginning of the year, the Q1 2022 saw projects for NFTs and NFT-related skills, such as Caricature & Cartoon Design, rank as the fastest growing skills on the platform growing by 30% compared to the previous quarter. During this same period, jobs for Bitcoin were down heavily by 31.1% and jobs for Ethereum began to fall by 23.9%. Q2 2022 saw projects for NFTs shift from the fastest growing jobs on the platform to the fastest falling, with a percentage decrease of 48.9% compared to the previous quarter. Jobs for Bitcoin also fell by 48%, while Ethereum and Blockchain projects fell by 33.9% and 32.9% respectively. Smart Contracts, NFT and Ethereum were amongst the fastest falling in Q3 2022, with most project numbers being cut in half during the quarter. Solidity, high-level language for implementing smart contracts, and Smart Contracts were the top fastest fallers, decreasing by 56.8% and 49.6% respectively. A comparison between Q4 2021 and Q4 2022 demonstrates how quickly these jobs have fallen in popularity from their dominance a year ago. NFTs, down by 75.4% (from 2,045 to 503), and Bitcoin, also down by 74.9% (from 1,518 to 381), took out the top spot for fastest falling project category year-on-year. These were followed by Ethereum, down 73.8% (from 2,340 to 613) and Solidity, down by 69.1% (from 1,988 to 614). ##### Freelancer Fast 50 The Freelancer Fast 50 index is the world’s largest forward indicator of trends in online jobs related to industries, technologies, products, and companies. The data is based on 372,000 jobs posted to the Freelancer platform between 1st October to 31st December 2022. Fast 50 Quarterly Index – Q4 2022 Fast 50 - Q4 Year-on-Year Comparison ###### About Freelancer.com Twelve-time Webby award-winning Freelancer.com is the world's largest freelancing and crowdsourcing marketplace by total number of users and projects posted. More than 63 million registered users have posted over 22.1 million projects and contests to date in over 2,000 areas as diverse as website development, logo design, marketing, copywriting, astrophysics, aerospace engineering and manufacturing. Freelancer owns Escrow.com, the leading provider of secure online payments and online transaction management for consumers and businesses on the Internet with over US$5 billion in transactions secured. Freelancer also owns Freightlancer & Loadshift, enterprise freight marketplaces with over 550 million kilometers of freight posted since inception. Freelancer Limited is listed on the Australian Securities Exchange under the ticker ASX:FLN and is quoted on OTCQX Best Market under the ticker FLNCF. Forward-looking statements This document contains certain "forward-looking statements". The words "anticipate", "believe", "expect", "project", "forecast", "estimate", “outlook”, “upside”, "likely", "intend", "should", "could", "may", "target", "plan" and other similar expressions are intended to identify forward-looking statements. Indications of, and guidance on, future earnings and financial position and performance, including Freelancer’s FY22 outlook, are also forward-looking statements, as are statements regarding Freelancer’s plans and strategies and the development of the market. Such forward-looking statements are not guarantees of future performance and involve known and unknown risks, uncertainties and other factors, many of which are beyond the control of Freelancer, which may cause actual results to differ materially from those expressed or implied in such statements. Freelancer cannot give any assurance or guarantee that the assumptions upon which management based its forward-looking statements will prove to be correct or exhaustive beyond the date of its making, or that Freelancer's business and operations will not be affected by other factors not currently foreseeable by management or beyond its control. Such forward-looking statements only speak as at the date of this announcement and Freelancer assumes no obligation to update such information. The release, publication or distribution of this document in jurisdictions outside Australia may be restricted by law. Any failure to comply with such restrictions may constitute a violation of applicable securities laws. Contact Details Marko Zitko +61 404 574 830 mzitko@freelancer.com Sebastian Siseles +1 415-801-2271 sebastian@freelancer.com

January 04, 2023 12:55 PM Eastern Standard Time

hVIVO contract the fruit of increasing Asian focus

hVIVO PLC

Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

January 04, 2023 08:37 AM Eastern Standard Time

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Hong Kong Baptist University-led research discovers new therapeutic target for irritable bowel syndrome

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 4 January 2023 - A research study led by scientists from the School of Chinese Medicine (SCM) at Hong Kong Baptist University (HKBU) has shown for the first time that the human gut bacterium Ruminococcus gnavus is a major trigger factor of diarrhoea-predominant irritable bowel syndrome (IBS-D). Based on this discovery, a new therapeutic target for the disease's treatment was identified. The study also found that low-protein food items such as fresh fruits, vegetables and bread may help reduce the gut motility in IBS-D. The research team of Professor Bian Zhaoxiang, Director of the Clinical Division and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies (middle); Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division (right); and Dr Zhai Lixiang, Post-Doctoral Research Fellow (left) of SCM at HKBU, has shown for the first time that the human gut bacterium Ruminococcus gnavus is a major trigger factor of diarrhoea-predominant irritable bowel syndrome. The research findings have been published in the internationally renowned scientific journal Cell Host & Microbe. Curative treatment for IBS-D needed Irritable bowel syndrome (IBS) is a common functional bowel disorder characterised by stool irregularities, abdominal discomfort and bloating. It has been estimated that about 7% of adults in Hong Kong are affected by IBS. IBS-D is the most common type of IBS and there is no known cure for the disease. Most clinical treatments for IBS-D focus on relieving symptoms. Previous research has demonstrated that the increased production of serotonin, a key neurotransmitter involved in the regulation of gut motility, contributes to the gastrointestinal symptoms displayed in IBS-D. It has also been shown that gut microbiota play a role in regulating the levels of serotonin. However, the bacterial species concerned and the molecular mechanism by which the gut microbiota modulate serotonin production remain unclear. Phenethylamine and tryptamine produced by Ruminococcus gnavus trigger IBS-D To explore curative treatment options for IBS-D, a research team co-led by Professor Bian Zhaoxiang, Director of the Clinical Division and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies; Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division; and Dr Zhai Lixiang, Post-Doctoral Research Fellow of SCM at HKBU, screened thousands of food components and their breakdown products in the fecal samples of 290 patients with IBS-D. They found that phenethylamine and tryptamine, two aromatic trace amines produced by the microbial digestion of dietary proteins, are highly enriched in IBS-D faeces, and they are associated with the severity of diarrheal symptoms in patients with IBS-D. Probing further, the researchers found that mice which had been fed with either phenethylamine or tryptamine experienced increased stool frequencies and colonic secretions, which are major symptoms of IBS-D. On the other hand, the team found that the gut bacterium Ruminococcus gnavus, which is enriched in IBS-D faecal samples, is a primary producer of phenethylamine and tryptamine. Furthermore, mice with this bacterium transplanted into their guts go on to develop IBS-D diarrheal symptoms. These results suggest that phenethylamine and tryptamine produced by Ruminococcus gnavus trigger IBS-D in mammals without the involvement of other risk factors of IBS-D. Phenethylamine and tryptamine stimulate serotonin production The research team further conducted a series of experiments to understand the mechanism by which phenethylamine and tryptamine lead to IBS-D. The results showed that phenethylamine and tryptamine directly stimulate the production of serotonin from the enterochromaffin cells in the gut through the activation of a trace amine-associated receptor (TAAR1), thereby stimulating gut motility and secretion disorders in IBS-D. The team then explored the therapeutic potential of targeting the phenethylamine/tryptamine/TAAR1 pathway for the treatment of IBS-D. It was discovered that inhibition of TAAR1 activation through the use of a specific inhibitor effectively alleviated the diarrheal symptoms in mice which had been transplanted with IBS-D faecal samples. Prospects for new therapeutic options "With a full outline of the mechanism of how gut microbiota associate with gut motility disorders, our research results suggest that the phenethylamine/tryptamine-mediated TAAR1 pathway is a new therapeutic target for IBS-D," said Dr Zhai Lixiang. "IBS-D patients experience frequent episodes of diarrhea with accompanying abdominal pain, which reduce the quality of life. The research discoveries offer promising potential for the development of therapies for IBS-D based on the inhibition of the pathway," said Professor Bian Zhaoxiang. The research team also found that a diet low in phenylalanine, an amino acid and a dietary precursor of phenethylamine, suppresses gut motility in mice by reducing the microbial production of phenethylamine and tryptamine. Low-protein food items such as fresh fruits, vegetables and bread have relatively low levels of phenylalanine. "Developing strategies to reduce the microbial transformation of dietary amino acids into phenethylamine and tryptamine, such as dietary intervention with reduced consumption of high-protein food items which usually have high phenylalanine levels, may represent a feasible approach for the management of IBS-D," said Dr Xavier Wong. Contact Details Christina Wu christinawu@hkbu.edu.hk

January 04, 2023 07:31 AM Eastern Standard Time

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News Release

Best Essay Writing Services in Australia: Top 10 Cheap Assignment Help Sites

Assignment Solutions

The world is replete with several secrets which can position you as one of the "most likely to succeed" people. One of these secrets is "delegation and help". This implies that you ask for professional help on whatever you cannot handle. After all, what counts best is that the job gets done, whether you worked on it or not. Most of the time, it is not the fact that you did it yourself. Thus, to help with your academic pursuits, there are online essay writing services to help you. So, if you have anything hindering your optimum performance in writing, you should reach out to them for help. For instance, you may not have a full grasp of the English language as a student in Australia. Or you are a postgraduate student who also doubles as the breadwinner for your family. You might have to work double jobs and not have time to work on many school papers that would be put on your academic table for the semester. These "write my essay" platforms exist for this exact reason. Here is the best part. We have painstakingly listed some of Australian essay writing services for your perusal. You might be interested in asking about the requirements for choosing these services. That is pretty simple. They are known by many of their clients as reliable platforms when it comes to academic writing. They are also the emblem of punctuality and respect for many students they offer services to worldwide. Their customer service is top-notch. And not only that, they create non-plagiarized content for you. Here is a list of the TOP10 essay writing services in Australia today: 99Papers - best essay writing service in Australia. Studdit - #1 custom writing website based in Sydney. PaperCoach - a top-rated assignment writing company. EssayBox - Australian professional writers to hire. Ivory Research - highest quality academic college papers. EssayPro - the cheapest writing/editing service in Australia. PaperHelp - #1 "do my essay" writing company from Melbourne. SpeedyPaper - the fastest essay writer for same-day papers order. MyAssignmentHelp - the oldest Australian assignment help provider. 1Essay - you can buy an essay in Australia with a good discount. So, are you ready to meet these writing services and read full review of each one? So, let's begin! 10 Best Australian Essay Writing Services 1. 99Papers 99Papers is the best essay writing service in Australia. With an array of experienced writers, they provide you with quality written essays every time. Their expert team has more than ten years of experience in academic writing. And they also have a wide range of topics they can handle without running out of resources. Furthermore, at 99Papers, customer satisfaction is a priority. And the numerous reviews online are a testament to this. They strive to provide customers with personalized services that meet all their needs. You can be sure that their team will ensure your paper meets your expectations, no matter how specific or complex. 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You can contact them via email, telephone, or live chat and expect prompt responses regarding any issue related to the paper order process, including payment processing options, delivery dates, etc. Finally, they understand how important confidentiality is for all customers. This is why all information related to orders, such as personal details, payment details, etc., are kept strictly confidential. And such details are only shared with prior consent from their clients, making them one of Australia's most reliable essay writing service providers now! 2. Studdit Studdit is a reputable assignment writing service in Australia that caters to the needs of students from all over the world. It provides customized solutions for students seeking help completing their assignments within a timeframe. And the team of qualified writers at Studdit works hard to ensure that all your assignments are completed on time. You should know that Studdit has been providing assignment writing services since 2020. And they have assisted thousands of students across Australia. Their team of experts works hard to understand each student's requirements thoroughly before starting the project, thus ensuring quality results within prescribed deadlines. They have expertise in subjects like English Literature, Mathematics, Nursing, Management Studies, etc., making them capable of handling any writing assignment task easily. Their offers include essay writing services for $10, including research paper help, dissertation editing, proofreading assistance, etc. These naturally cover subjects such as Science & Technology, Business Administration & Economics, etc. Moreover, they also offer expert guidance on formatting and referencing styles used in different kinds of assignments like essays, dissertations, etc. Thus, with Studdit, you can be assured of getting quality work done within your stipulated timeline without worrying about errors or plagiarism issues. Besides offering reliable assistance for academic projects, Studdit also provides professional consultation regarding career choices and tips and advice on how best to structure resumes & CVs based on the specific job requirement. Thus, it is a premier online platform for students seeking guidance and assistance for academic and career development goals. So, they are a reliable plug if you want to buy an essay in Australia. 3. PaperCoach PaperCoach is one of the leading online assignment writing services in Australia. Their services range from editing and proofreading to creating an entire paper from scratch for just $7.99. With its team of professional writers and editors, PaperCoach provides quality work that meets all requirements set out by universities or colleges in Australia. So, are you a student looking for a reliable 'write my essay for me' plug? Then this is for you. PaperCoach has a simple approach to providing top-notch help for students. It starts by assessing the student's needs and understanding the expectations of their respective university. This would help them formulate a comprehensive plan for delivering quality work on time. All assignments are customized according to individual requirements. And they do all these while ensuring each one is properly researched and proofread before submission. Hence, no plagiarism issues arise during the assessment. 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Overall, with its professional approach towards providing top-notch services and an excellent customer support system, Essay Box stands out amongst all other essay writing service providers available in Australia today. As a result, they are indeed an ideal place to buy essays in Australia. 5. Ivory Research Ivory Research has its place among the best essay writing services in Australia. It provides many student services, including essay writing, thesis and dissertation assistance, coursework writing help, editing and proofreading services, and more. The company has been serving the needs of students since 2005. And it has helped thousands of them write high-quality essays that have earned them top marks and improved their academic performance. The company is committed to providing quality work within tight deadlines and offers an on-time delivery guarantee that ensures all assignments are submitted before the deadline for just $120. 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They focus on delivering quality academic papers that meet the standards of educational institutions and help students achieve their desired grades. One thing with PaperHelp is that they understand that each student has different needs, so they ensure their writers are equipped with unique skills and resources to help them craft customized essays according to clients' requirements. Generally, the writers assigned to your project are professionals with years of experience dealing with similar assignments. Further, the company also takes pride in its customer service team, which is available 24/7 for any queries or concerns related to your assignment. PaperHelp provides free unlimited revisions until you're completely satisfied with your order before the submission deadline approaches, so you can be sure that you will get what you paid for! Moreover, customers can also benefit from various discounts on the website when placing an order for a large number of pages or more than two orders simultaneously - this helps reduce costs considerably without compromising quality! And yes, with just $17 per page for undergraduate papers, you can get the best deal with them. PaperHelp has stringent measures, such as secure payment systems (SSL encryption). So, there are no risks involved while making payments online. Furthermore, they assure complete anonymity by never sharing personal data with third parties. Thus, ensuring the safety and privacy of customers' information at all times. Not only do they provide customer support, but they also offer tips and advice on how best to approach tasks related to essay writing. And this certainly sets them apart from other competitors within the Australian market. To sum up, PaperHelp is one of Australia's best essay writing services. And that’s simply due to their proven track record & commitment to delivering high-quality content at competitive prices and an excellent customer satisfaction rate, ensuring customers always get value for money! 8. SpeedyPaper SpeedyPaper is well known as one of Australia's best essay writing services. It is a trusted and legitimate academic assistance provider offering many services to students across the country. The company provides high-quality essays that are custom-made for each client. Thereby meeting all unique requirements that you might bring their way. SpeedyPaper employs professionals who have extensive experience in their field. And this ensures that every essay they deliver meets the highest standards and exceeds expectations. An essential feature of SpeedyPaper's service is its affordability. Its prices are lower than other essay-writing providers available on the market. With only $9 per page, you can get a great essay with them. This makes it an attractive option for students on tight budgets who need help with their essays without breaking the bank. The company also offers discounts to make its services even more affordable for customers. Interestingly, this is something that few other services are provided in Australia today! With SpeedyPaper, there's no risk involved when ordering an essay. You can be sure you will receive high-quality work at a fair price. They guarantee absolute satisfaction with your purchase and ensure you won't feel ripped off like other services. Just so your heart is at rest, know that all papers submitted by SpeedyPaper undergo strict plagiarism checks to ensure they are 100% uniquely produced and free from copying or cheating. And guess what? This again reflects the quality assurance this service provider provides compared to others offering similar services in Australia. When it comes to deadlines, SpeedyPaper has got that end covered too. All orders are delivered within agreed deadlines, no matter how urgent they may be! They understand how important punctuality is for their clients. They also take extra measures to ensure that everything runs smoothly throughout every stage of the process. That is, from placing an order to receiving it back completed. They also offer customers 24/7 support so you can contact them whenever needed should any queries arise during your order or after receipt. If you're seeking a reliable and affordable essay writing service provider in Australia, look no further than SpeedyPaper! Their commitment to excellence combined with great prices makes them an ideal choice when seeking help with completing academic tasks such as essays or assignments quickly and professionally without blowing your budget away. 9. MyAssignmentHelp MyAssignmentHelp is one of the best essay writing services in Australia. Like every other service on this list, they have mastered providing high-quality essay help services to students in the country. The company has been offering academic writing assistance for over ten years. And that has earned them a reputation for being one of the most reliable and trustworthy services. Also, this company offers an extensive range of essay writing services catering to various academic levels, including undergraduate, Masters, and PhD programs. It assists with all types of essays, including argumentative essays, case studies, reflective essays, expository essays, analytical essays, and so on. MyAssignmentHelp also offers other services such as proofreading and editing, creating an outline for an essay or thesis paper, etc. The primary objective of MyAssignmentHelp is to provide quality work at an affordable price of $30 with a fast turnaround time. Its team comprises qualified professionals with more than ten years of experience in academic writing; they are always ready to assist students in completing their assignments with utmost precision. And they do this within a tight deadline as required by your university or college professors/instructors. In addition, MyAssignmentHelp ensures that all your assignments are tailored according to your specific requirements by assigning dedicated writers to you. These writers are well-versed in the subject matter you have opted for. The writers go through several plagiarism checks before submitting the finished work to ensure one hundred per cent uniqueness and originality while ensuring accuracy and correctness through grammar checks. This is usually achieved via Grammarly software. Apart from this, they take extra measures like revising their work multiple times to make sure there isn't even a single mistake present. Alongside helping students secure good grades, MyAssignmentHelp also helps them gain confidence about their coursework topics since every assignment provided will be written taking this into account. Overall, My Assignment Help is exceptional in providing quality papers at affordable prices within the deadline set by the student himself. Thus, making life simpler than ever before! 10. 1Essay 1Essay is one of Australia's leading and most reputable essay writing services. Its mission is to provide top-notch quality essays that meet the academic standards set forth by universities and colleges across the country. The talented writers, editors, and customer support staff guarantee each client a paper that meets their needs. 1Essay offers a wide range of services tailored toward providing students with an efficient way to quickly and efficiently complete complex assignments. Their essays go for $31 per page. They provide an array of essay writing services, including simple essays, book reports, research papers, dissertations, thesis statements, and term papers, as well as proofreading services for those who need them. In addition, 1Essay also provides editing and formatting help for those struggling with their essay structure or presentation style. The team at 1Essay takes the time to understand each student's unique writing style so they can provide them with highly customized results that match their individual needs perfectly. They have experts in many fields, such as English literature, law, nursing, and business, who can craft high-quality essays tailored exclusively to each customer's specific requirements, regardless of how demanding they may be. A crucial part of what makes 1Essay so popular among students is its commitment to delivering only original content with no plagiarism whatsoever. And they do this by using advanced plagiarism detection software before every submission is sent out for evaluation. This ensures all work produced has been thoroughly checked against existing sources online so customers can be sure they will not get penalized by their professors or institutions due to unintentional mistakes or intentional plagiarism when using 1essays services. Frequently Asked Questions Are essay writing services legit in Australia? Yes, essay writing services are legit in Australia. They are becoming popular for students seeking assistance with their academic workload. As the demand for quality education and work experience increases, more students seek help writing essays. Essay writing services provide high-quality customized essays that reflect an individual's unique style and creativity. These services guarantee on-time delivery, high-quality papers, and reliable customer service. Additionally, essay writing services ensure the privacy and security of all customers' personal information by using secure payment methods. With these features in place, it is evident that essay writing services in Australia are legit and trustworthy sources of assistance to students who need help tackling complex topics or require help with the basics of essay structure. Where can I publish my essay in Australia? Many options are available to those looking to publish their essays in Australia. If you are a student or academic, submitting your essay to an academic journal is one option. Most journals will require that you adhere to their guidelines and have your work peer-reviewed before publication, but this can open up a range of opportunities, including presenting at conferences and furthering your career. Social media outlets like Twitter, Facebook, and LinkedIn are another avenue for publishing essays; these platforms allow users to post content to engage with like-minded individuals on various topics. Furthermore, various online publishers accept essay submissions; websites such as PaperCoach offer a student's work to be published and read by potential employers, peers, or other interested parties. Finally, if writing is not something you wish to take up professionally, why not consider submitting it locally? Newspapers often host columns written by community members and can provide an excellent way for someone's views or stories to be shared with a larger audience. How do you get an A+ on an essay? Essay writing/editing services provide college students with professional help to ensure they get an A+ on their essays. These services offer a range of features, such as expert writers with experience and knowledge in the area, customized essays tailored to individual needs, and editing and proofreading services to catch any errors. The writers can create a piece from scratch or edit existing drafts to ensure it's up to standard. Furthermore, these services offer timely delivery so students can submit their essays on time without worrying about deadlines. There’s more. The writers also check for plagiarized content in the essay before delivery. All of these features combined make essay writing services ideal for achieving high grades on essays! Is it worth paying someone to write an essay? It’s a true assertion today that paying a writer to write an essay for you is smart. After all, writing an essay can be difficult and requires a lot of research, time, and effort. Moreover, many people lack the necessary skills or the time to write quality essays. So, they chose to outsource the assignment to expert writers who were more experienced in essays and had the resources required to produce excellent work. Engaging skilled writers gives you access to expert advice on your topic. And this can enhance the outcome, making the piece more effective. Proven writers usually have access to rich research materials that are typically unavailable or too expensive for a lot of customers. Likewise, the writers place a high value on deadlines and will go to any length to produce excellent submissions within given time frames. Overall, it is worth paying someone with experience in writing essays as they will bring expertise regarding structure and content and other skills needed for successful essay writing. Requirements for essay writing in Australia colleges Essay writing is an essential element of the study process in Australian colleges, as it allows students to develop their critical thinking skills, research capabilities, and communication abilities. As such, students must understand the requirements for good essay writing in Australian colleges. To write a good essay in an Australian college setting, students need to clearly understand what type of essay they are writing and how much time will be dedicated to each step of the process. We often encounter two kinds of essays: argumentative and narrative. Argumentative essays require that students take a stance on an issue and provide evidence supporting their opinions; narrative essays require that students tell a story using facts or other data. Apart from knowing which type of essay they will be writing, students must take certain steps to ensure that their work is up-to-standard. First, before starting any essay project, you must research the topic; this should include reading relevant material from books and online sources and conducting interviews with experts or those knowledgeable about the subject matter. Additionally, brainstorming should occur before any actual writing occurs to generate ideas on how best to approach the topic. After completing these initial steps, it's time for drafting. Students should create an outline for effective content organization and time management here. A good outline also helps with other tasks like editing or proofreading without having much difficulty transitioning between points within their work. When all necessary information has been collected and organized, it is time to begin putting words down onto paper. Here making sure that all arguments are supported with evidence is paramount (facts/figures/theories etc.) Try using credible external sources when making arguments instead of purely relying on opinion alone. This gives your work greater validity both internally (in terms of structure) & externally (in terms of credibility). Furthermore, always remember to write and answer questions such as "why?" & "how?" – these questions are helpful in strengthening your points! At last, when you feel confident about your essay, ensure you edit/proofread your work thoroughly before handing it in. That way, you will not miss anything. Instead, the final piece gets improved further! In conclusion, while there may be different requirements depending on the university/college, good essay writing requires organization & preparation beforehand, along with thorough editing afterwards if successful results are desired. These tips often ensure candidates pass with good grades every single time! What is the appropriate price to engage an Australian writer for an essay? The cost of hiring an Australian writer for an essay depends on some factors such as the number of pages required, the complexity of the topic, the deadline, and any specific requirements from the customer. On average, an essay of four pages may cost between $60 and $100 for an expert writer in Australia. More complex essays with additional research and full formatting requirements can cost up to $300-400. Likewise, prices may also differ based on the writer whose services you engage, whether an experienced freelance writer or a professional writing service. However, the most popular writing companies will offer good discounted rates for repeat customers. Additionally, there may be discounts available for bulk orders and long-term projects. Can I get caught buying an essay online? No! You cannot get caught when you buying an essay online. One of the advantages of purchasing an essay online is that you can remain anonymous and avoid being caught. As long as you use a reputable website, research the writer, and make sure all payments are secure, there's no danger of getting caught buying essays online. You can also trust the anonymity of your personal information and your payment. Good websites will have privacy policies to protect their customers from data breaches or misuse. Additionally, before finalizing a purchase for an essay online, you should ensure that there are plagiarism checks in place so your professor won't be able to detect any similarities with other sources and thus trace them back to you. Following these practices guarantees, you won't get caught when buying essays online. How can I find a good essay writer? Finding someone in Australia to write your essay can seem daunting, but it doesn't have to be! There are several reliable websites online that you can use to find a professional writer. Websites like 99Papers and PaperHelp both offer a variety of writing services from professionals all over the world. With these sites, you can read customer reviews and look at samples before deciding who will write your paper. You might also try searching for freelance writers on social media platforms like LinkedIn or Twitter. Make sure the person you choose has sufficient experience in the topic you need help with and is willing to meet any deadlines that your professor or school may set. What platform offers the best essay writing service in Australia? 99Papers is the best essay writing service in Australia, and it provides students with high-quality essays that experienced professionals write. With 99Papers, students can get essays of all kinds, from analytical to argumentative to persuasive. The essays cover issues from different academic fields, such as law, finance, history, literary study, and science. Of course, the writers have years of experience providing top-notch essays on these topics. Furthermore, the company provides excellent customer service with quick turnaround times; its team is available 24/7 for any queries or revisions needed on the essays they deliver. All their services are cost-effective and offer discounts to frequent customers. So, no matter what kind of essay you need help with, 99Papers is undoubtedly the go-to spot for all your academic needs! Summing up One thing is certain - those who call for help are more likely to get help than those who do not ask at all. Thus, if you ask for help any aspect of need, you are more likely to get responses. The same principle applies to academic writing. Your papers, such as term papers and research papers of any kind, can be taken care of if you have no means of working on them. However, this is if you ask for professional help with essay writing services online. They are always available to help with any of your academic writing needs. So, what should your resolve be now? Request the help of these services listed above. They are rich in resources that would be deployed to give your essay the best professional touch it requires. Thus, you can rest assured of a top grade in your academic pursuits when you reach out and order from them. So, what do you need today? An essay or anything in this line? Then reach out to any of these essay writing services in Australia above. Contact Details Eric Blout eric.blout@myassignment.shop Company Website http://myassignment.shop

January 03, 2023 08:05 PM Eastern Standard Time

Bellevue Healthcare Trust expects "incredible volte-face" to be a key factor in 2023

Bellevue Healthcare Trust PLC

Contact Details Proactive Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

January 03, 2023 06:48 AM Eastern Standard Time

Video

The Year of the Tripledemic

RazorPitch/BIXT

COVID-19 may have lost its daily news headline status, but the disease rages on with 2700 weekly deaths in the U.S. and millions of Americans chronically disabled from long-COVID, 4 million of which are being kept from work. This winter time, a terrible year for RSV as well as a potentially worse flu season could add insult to injury especially when one considers the fact that COVID-19 leaves some people with an impaired immune system similar to what HIV does to cause AIDS. The multiplication of disease could amplify the risks of influenza and RSV to result in more severe cases of these diseases which may result in increased deaths and morbidity. And that isn’t something our country nor the world can afford. There are already reports of Tamiflu generics being in short supply, and it’s just barely the New Year. Fortunately, there are several biotech and pharma companies advancing solutions for RSV, flu, and COVID, including two that may have a solution for all three of these viruses that are currently plaguing the U.S. However, deciding which ones are worth an investment in is not necessarily an easy task. 5 Biotech and Pharma Companies Spearheading Viral Tripledemic The first company that everyone thinks of when considering COVID-19 solutions is Pfizer (NYSE: PFE). With the Comirnaty COVID vaccine and 3CL inhibitor Paxlovid, the company’s COVID antiviral, the company is in a market-leading position for COVID, raking in tens of billions in revenues for both products. What is less well-known is that Pfizer is also on a roll with RSV. The company announced in November that its RSV vaccine candidate used in maternal immunization for infants was effective against infant death, making it likely the first available maternal vaccine to protect against infant RSV death. The vaccine is also effective in older adults. And if that weren’t already enough, the company acquired ReViral and its RSV therapeutics for $525 million, including upfront and milestone payments, with an expectation that the therapeutics would bring in $1.5 billion to Pfizer. ReViral’s main candidate is a fusion inhibitor sisunatovir which is in phase 2. Pfizer is also initiating a phase 3 study for its influenza vaccine, making it a leader in the tripledemic. Indeed, its 2022 COVID revenue is expected to be over $50 billion. Big Pharma competitors GSK (NYSE: GSK) and Roche are also key players in the tripledemic race. Roche was the initial innovator of the influenza antiviral blockbuster, Tamiflu, but the company has made recent progress with COVID, too. The company is well known for its IL-6 inhibitor (an anti-inflammatory monoclonal antibody) approval in severe COVID-19. For next steps against influenza, the company has developed a new therapeutic called baloxavir marboxil, aka Xofluza, which unfortunately has some severe drawbacks in causing drug resistance mutations at quite a high rate such that it’s not necessarily a good choice for kids. This could derail its blockbuster follow-up to the Tamiflu success seen years ago. Roche is certainly outshined by Pfizer in the Tripledemic race. GSK’s progress is more straightforward. Known for its prowess in the antiviral space, GSK was granted a priority review and PDUFA date of May 23, 2023 from the FDA due to its RSV vaccine candidate achieving a high 82.6% efficacy in its pivotal trial. The company has early stage monoclonal antibodies and vaccines against influenza, as well as late-stage studies for COVID-19 vaccines and neutralizing antibodies. What’s missing are antiviral candidates for the diseases, and so while one might call GSK a leader in the tripledemic, they are also outshined by Pfizer. One smaller company, Icosavax (NASDAQ: ICVX), is advancing vaccine candidates for all three diseases, but the one drawback is that they’re not past phase 1 for any of their candidates. The company’s secret sauce lies in its VLP (virus-like particle), which allows viral proteins to be assembled more similarly to an actual virus and is supposed to improve the immune response compared to vaccines that use these proteins alone, like mRNA vaccines. The company recently hit the headlines with positive phase 1 clinical trial results for its RSV vaccine with sustained neutralizing antibody responses through 6 months; durability of response was a key reason for developing VLP vaccines. Icosavax is moving forward with this vaccine in combination with its hMPV virus-like particles as the only vaccine for the elderly population targeting the two leading causes of pneumonia. ICVX is particularly well funded with $229 million in current assets reported at the end of Q3 2022, which appears sufficient to support the company for more or less than 2 years based on their current burn rate. Unfortunately, for common yearly diseases like COVID, influenza, and RSV, vaccines are only a partial answer. Another small pharma company, Bioxytran Inc. (OTCMKTS: BIXT), might have antiviral treatment solutions for all three viruses. Bioxytran recently released slam-dunk results from their ProLectin-M antiviral, which had a 100% response rate reducing the viral load of COVID-19 patients to undetectable levels in just a few days, effectively curing every single patient on the drug. These results are unprecedented and quite possibly the best COVID antiviral results ever recorded. The company’s drugs are made using carbohydrate chemistry which usually means a benign safety profile. Unbeknownst to most investors, the company appears to be working on or considering treating other viruses including influenza and RSV, and if BIXT can show its RSV and influenza antivirals work like its COVID antiviral, then the company would have multiple potential blockbuster products. ProLectin-M is a phase 3 ready drug with results expected in 2023. Conclusion These leading tripledemic companies are focusing on the current and future problems facing the nation. But when it comes to investment risk and reward, there are two clear winners. With respect to the bigger pharma companies with established sales, Pfizer is by far the undisputed COVID-19 champion with a forward P/E ratio of ~8x compared with GSK at ~11 and Roche at ~14. Market leadership typically comes with a premium price tag so Pfizer is clearly the best value when looking at market leadership and forward price/earnings ratios. However, multi-bagger returns are unlikely to be seen with big pharma. Bioxytran, however, appears to be a smaller biotech that could return multiples to investors. Big Pharma is licensing COVID-19 antiviral candidates from various biotech companies for hundreds of millions in deal value, and some of these companies are already worth that in market capitalization. When considering the value of each of the companies, Bioxytran stands out with just a $50 million market capitalization and a phase 3 ready COVID-19 antiviral that appears to best Paxlovid in effectiveness. This compares favorably to Icosavax’s $350 million market cap based on three phase 1 assets. With positive phase 3 results or a pharma licensing agreement, BIXT shares could see a rerating higher, potentially to the much more reasonable $350 million dollar range, or 7x the current price. Investors might consider a dual investment in PFE and BIXT to take advantage of the tripledemic and bolster portfolio returns. Razorpitch Inc. is a marketing communications and investor relations firm serving private, pre-IPO, and public companies. RazorPitch specializes in corporate, investor, and stakeholder communications, with a primary focus on sponsored media. Our goal is to raise visibility, expand awareness, and increase value. To learn more, visit RazorPitch.com. Disclaimers: The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor in regard to forward-looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, assumptions, objectives, goals, assumptions of future events or performance are not statements of historical fact may be forward looking statements. 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RazorPitch is not operated by a licensed broker, a dealer, or a registered investment advisor. It should be expressly understood that under no circumstances does any information published herein represent a recommendation to buy or sell a security. RazorPitch authors, contributors, or its agents, may be compensated for preparing research, video graphics, and editorial content. RazorPitch has not been compensated to produce this content. As part of that content, readers, subscribers, and webs are expected to read the full disclaimers and financial disclosure statement that can be found on our website. Contact Details RazorPitch Mark McKelvie +1 585-301-7700 Mark@RazorPitch.com Company Website http://razorpitch.com

January 03, 2023 05:00 AM Eastern Standard Time

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